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Common name: Colistin Sulfate Soluble Powder Composition: Colistin Character: White or off-white powder. Pharmacological effect: Pharmacodynamics: Colistin is a polypeptide antibacterial drug, which is a kind of alkaline cationic surfactant. By interacting with phospholipids in the bacterial cell membrane, it penetrates into the bacterial cell membrane and destroys its structure, thereby causing changes in membrane permeability, resulting in the death of bacteria and a bactericidal effect. It has strong antibacterial effect on Gram-negative bacteria such as aerobic bacteria, Escherichia coli, Haemophilus, Klebsiella, Pasteurella, Pseudomonas aeruginosa, Salmonella and Shigella. Gram-positive bacteria are usually not sensitive. There is complete cross-resistance with polymyxin B, but no cross-resistance with other antibacterial drugs. Pharmacokinetics: The drug is barely absorbed by oral administration, but is rapidly absorbed by gastrointestinal administration. The drug entering the body can be rapidly distributed into the heart, lungs, liver, kidney and skeletal muscle, but not easily into the cerebrospinal cord, thoracic cavity, joint cavity and infected lesions. It is mainly excreted via kidney. Medicine interaction: ① Combined use with neuromuscular blocking agents such as muscle relaxants and aminoglycosides may cause muscle weakness and apnea. ② It has a synergistic effect with chelating agent (EDTA) and cationic detergent on Pseudomonas aeruginosa, and is often used in combination for the treatment of local infections. Indication:Polypeptide antibiotics. Mainly used for the treatment of intestinal infections caused by gram-negative bacteria. Usage and dosage: Based on this product. Mix drinking: 0.4-2g for swine and 0.2-0.6g for poultry: 1L water; Mixed feed: 0.4-0.8g for swine: 1kg feed. Adverse reaction: No adverse reactions have been observed when used in accordance with the prescribed dosage. Note: Layers are prohibited during the laying period; It should not be used continuously for more than one week. Withdrawal period: Swine,poultry, 7 days. Specification: 100g:10g (300 million units) Pack size: 500g/bag, 16 bags/box. Storage: Sealed and stored in a cool, dry place. Shelf life: 24 months. Email： director@chinathinkhigh.com Wechat/whatsapp: 0086-15098592009 |
