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Common name: Florfenicol Powder Composition: Florfenicol Character: White or off-white powder. Pharmacological effect: Pharmacodynamics: Florfenicol belongs to the broad-spectrum antibiotics of amido alcohols and is a bacteriostatic agent. It plays a role by binding to the ribosomal 50S subunit to inhibit the synthesis of bacterial proteins. It has strong antibacterial activity against a variety of Gram-positive bacteria and Gram-negative bacteria. Pasteurella hemolyticus, Pasteurella multocida and Actinobacillus pleuropneumoniae were highly sensitive to florfenicol. The antibacterial activity of florfenicol against many microorganisms in vitro is similar or stronger than thiamphenicol, and some bacteria resistant to amide alcohols due to acetylation, such as Escherichia coli and Klebsiella pneumoniaemay still be sensitive to florfenicol. It is mainly used for bacterial diseases of swine, poultry and fish caused by sensitive bacteria, such as Pasteurella haemolytica, cattle and swine respiratory diseases caused by Pasteurella multocida and Actinobacillus pleuropneumoniae. Salmonella caused by typhoid and paratyphoid fever, chicken cholera, chicken dysentery, Escherichia coli disease, etc.; fish bacterial septicemia, enteritis, erysipelas caused by Pasteurella, Vibrio, Staphylococcus aureus, Enterococcus, etc. Pharmacokinetics: Florfenicol is rapidly absorbed internally, reaching therapeutic concentrations in the blood after about 1 hour, and peak blood concentrations can be reached in 1-3 hours. The bioavailability reaches more than 80%. Florfenicol is widely distributed in animals and can cross the blood-brain barrier. It is mainly excreted from urine in its original form, with a small amount excreted in feces. Medicine interaction: ①Macrolides and lincosamides have the same target of action as this product, both of which bind to the 50S subunit of the bacterial ribosome, and may have a mutual antagonistic effect when combined. ②May antagonize the bactericidal activity of penicillins or aminoglycosides, but this has not been demonstrated in animals. Indication:Amino alcohol antibiotics. For Pasteurella and Escherichia coli infections. Usage and dosage: Based on Florfenicol. Oral administration: 20-30mg per 1kg of body weight for swine and poultry, twice a day for 3-5 consecutive days; 10-15mg for fish, once a day for 3-5 consecutive days. Adverse reaction: This product has some immunosuppressive effects when used at higher than recommended doses. Note: Layers are prohibited during the laying period; Breeders should be used with caution; There is embryotoxicity, pregnant and lactating livestock should be used with caution; Animals during the vaccination period or with severe immune deficiency are prohibited; Animals with renal insufficiency need to reduce the dose or prolong the dosing interval. Withdrawal period: Swine 20 days, poultry 5 days, fish 375 days. Specification: 20%, 30% Pack size: 500g/bag, 16 bags/box. Storage: Sealed and stored in a dry place. Shelf life: 24 months. Email： director@chinathinkhigh.com Wechat/whatsapp: 0086-15098592009 |
